Intestinal Enterokinase Deficiency: A Newly-recognized Disorder of Protein Digestion
نویسندگان
چکیده
منابع مشابه
Newly-recognized Disorder of Protein Digestion
Enterokinase is an enzyme secreted by the mucosa of the small intestine and is responsible for the conversion of trypsinogen to its active product, trypsin. Its key role in initiating the formation of proteolytic enzymes from their inactive precursors is illustrated in Fig. 1. When the pancreatic zymogens reach the duodenum, trypsin is formed by the action of enterokinase on trypsinogen and thi...
متن کاملIntestinal enterokinase deficiency.
Enterokinase is an enzyme secreted by the mucosa of the small intestine and is responsible for the conversion of trypsinogen to its active product, trypsin. Its key role in initiating the formation of proteolytic enzymes from their inactive precursors is illustrated in Fig. 1. When the pancreatic zymogens reach the duodenum, trypsin is formed by the action of enterokinase on trypsinogen and thi...
متن کاملEnterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains.
Enterokinase is a protease of the intestinal brush border that specifically cleaves the acidic propeptide from trypsinogen to yield active trypsin. This cleavage initiates a cascade of proteolytic reactions leading to the activation of many pancreatic zymogens. The full-length cDNA sequence for bovine enterokinase and partial cDNA sequence for human enterokinase were determined. The deduced ami...
متن کاملSignificance of Intestinal Digestion of Dietary Protein
In the last twenty years, elaborate models have been developed to formulate diets with greater accuracy in meeting the protein and amino acid requirements of lactating dairy cattle. Models for feeding protein to dairy cattle in the USA evolved from basic crude protein (NRC, 1978) to more complex systems based on rumen undegraded protein (RUP) and intestinal digestion of RUP (NRC, 2001). The NRC...
متن کاملIntestinal enterokinase deficiency. Occurrence in two sibs and age dependency of clinical expression.
Intestinal enterokinase deficiency in 2 sibs in described. A boy failed to gain weight and had vomiting, diarrhoea, oedema, hypoproteinaemia, and anaemia in early infancy. His duodenal juice contained very low or absent proteolytic enzyme activity, which increased markedly after addition of enterokinase. He was treated with pancreatic extract and gained weight rapidly. At 44 months of age he is...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1970
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.45.243.651